Key result
Lipopolysaccharide administration decreased IGFBP-3 serum levels and hepatic gene expression in both adrenalectomized and sham-operated rats, suggesting the decrease is not mediated by glucocorticoids.
The decrease in hepatic IGFBP-3 gene expression induced by endotoxin (LPS) is not mediated by glucocorticoids.
Indicates glucocorticoid-independent IGFBP-3 downregulation by endotoxin in rats; leaves open mechanistic relevance to human sepsis.
The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.
No takes yet. Share an insight, caveat, or question.
Priego et al. (2002) studied Endotoxic shock. Lipopolysaccharide (LPS) administration was evaluated on IGFBP-3 serum levels and hepatic IGFBP-3 gene expression. Lipopolysaccharide administration decreased IGFBP-3 serum levels and hepatic gene expression in both adrenalectomized and sham-operated rats, suggesting the decrease is not mediated by glucocorticoids.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: