Key result
Acute normovolemic hemodilution decreases total peripheral resistance through endogenous nitric oxide synthesis, whereas neural reflexes do not modulate this systemic vascular response.
Population
Male Sprague-Dawley rats (three groups)
Comparison
Acute normovolemic hemodilution with or without… vs Baseline/control values
Design
Preclinical
Authors
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ANH vasodilation is NO-mediated in animals; leaves open translation to human perioperative hemodynamics.
Systemic vasodilation during normovolemic hemodilution is mediated by endogenous nitric oxide synthesis rather than neural reflexes.
Doss et al. (1995) studied this question. Acute normovolemic hemodilution vs. Baseline/control values was evaluated on Total peripheral resistance and cardiac output. Acute normovolemic hemodilution decreases total peripheral resistance through endogenous nitric oxide synthesis, whereas neural reflexes do not modulate this systemic vascular response.
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