Key result
Neonatal cord blood neutralizing antibody titers were significantly lower than maternal titers for coxsackie B5 (P<0.031) and echovirus 11 (P<0.005).
Population
98 matched mothers' serum and neonatal cord blood pairs at term, and 7 neonates
Design
Cross-sectional
Authors
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Neonates may have reduced enterovirus protection at birth; hypothesis-generating for maternal immunization to boost passive immunity.
Cross-Sectional (n=98)
p-value: p=<0.031
A large percentage of neonates are born with low titers of enterovirus-neutralizing antibody, which may be disproportionately lower than maternal titers for certain enteroviruses.
Hammond et al. (1985) conducted a cross-sectional in Enterovirus susceptibility (n=98). Neonatal cord blood vs. Maternal serum was evaluated on Geometric mean titers of neutralizing antibodies to coxsackieviruses and echovirus 11 (p=<0.031). Neonatal cord blood neutralizing antibody titers were significantly lower than maternal titers for coxsackie B5 (P<0.031) and echovirus 11 (P<0.005).
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