Key result
Cord blood seropositivity for E11 reaches only ~18%, leaving most newborns susceptible.
Why the study?
Echovirus 11 and coxsackievirus B3 cause important neonatal infections, but few investigations have examined enterovirus D68 infection in neonates.
Population
222 parturient women aged 20-46 years old (gestational age 34-42 weeks)
Design
Cross-sectional seroprevalence study
Authors
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Low E11 seropositivity may signal neonatal vulnerability; leaves open prospective studies on surveillance or maternal immunization.
Cross-Sectional (n=222)
p-value: p=<0.001
A large proportion of newborns in Taiwan are susceptible to echovirus 11 due to low maternal transplacental antibody transfer, highlighting a potential risk for severe neonatal infections.
Hu et al. (2023) conducted a cross-sectional in Neonatal enterovirus infection susceptibility (n=222). Enterovirus (E11, CVB3, EVD68) exposure was evaluated on Cord blood seropositive rates for E11, CVB3 and EVD68 (p=<0.001). Cord blood seropositive rates among 222 parturient women were 18% for E11, 60% for CVB3, and 95% for EVD68 (P<0.001), leaving a large proportion of newborns susceptible to E11.
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