Key result
The Minnesota Living with Heart Failure Questionnaire score correlated with most SF-36 domains (r=-0.38 to -0.69), depressive symptoms, physical activity, and systolic function.
Why the study?
Chagas cardiomyopathy compromises health-related quality of life, but no specific instrument exists for these patients, making it necessary to verify the validity of the Minnesota Living with Heart Failure Questionnaire in this population.
Is the Minnesota Living with Heart Failure Questionnaire (MLwHFQ) valid for assessing health-related quality of life in patients with Chagas cardiomyopathy?
Cross-Sectional (n=50)
Is the Minnesota Living with Heart Failure Questionnaire (MLwHFQ) valid for assessing health-related quality of life in patients with Chagas cardiomyopathy?
Effect estimate: r = -0.38 to -0.69
The MLwHFQ is a valid tool for assessing health-related quality of life in patients with Chagas cardiomyopathy, correlating well with other established metrics of physical and mental health.
MLwHFQ may support HRQoL assessment in ChC patients; leaves open need for larger validation and disease-specific tools.
OBJECTIVE: Chagas cardiomyopathy (ChC) is the most severe clinical form of Chagas disease and, in association with psychosocial factors, can compromise the health-related quality of life (HRQoL) of affected patients. To date, there is no specific instrument to assess the HRQoL of these patients, and the Minnesota Living with Heart Failure Questionnaire (MLwHFQ), specific for heart failure, is being used both in research and current clinical practice. Therefore, we aimed to verify the validity of the MLwHFQ in the assessment of HRQoL of patients with ChC. METHODS: Fifty patients with ChC (50.6 ± 10.1 years, NYHA I-III) were evaluated. The MLwHFQ, Short-Form of Health Survey (SF-36), Beck Depression Inventory (BDI), and Human Activity Profile (HAP) were applied. All patients underwent echocardiography and Cardiopulmonary Exercise Testing (CPET). RESULTS: The MLwHFQ score correlated with almost all SF-36 domains (with r-value ranging from -0.38 to -0.69), except pain (p = 0.118). The MLwHFQ score also correlated with the BDI score (r = 0.748; p < 0.001), HAP score (r = -0.558; p = 0.001), peak oxygen uptake (r = -0.352; p = 0.01), and left ventricular ejection fraction (r = -0.329; p = 0.021). There was no significant difference in the score found on the MLwHFQ among NYHA classes (p = 0.101), as well as between patients with systolic dysfunction (n = 30) and preserved cardiac function (n = 20) (p = 0.058). Similarly, there was no significant difference in the score found on the physical (p = 0.423) and mental (p = 0.858) components of SF-36 between patients with systolic dysfunction and preserved cardiac function (p = 0.271 and p = 0.609, respectively). There was also no difference in the mental component of SF-36 among NYHA classes (p = 0.673). However, the HRQoL using the physical component of SF-36 was worse in advanced NYHA classes (p = 0.014). CONCLUSION: MLwHF correlated with most SF-36 HRQoL domains, depressive symptoms, physical activity, and systolic function and seems to be valid in assessing the HRQoL of ChC patients.
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Trindade et al. (2023) conducted a cross-sectional in Chagas cardiomyopathy (n=50). Minnesota Living with Heart Failure Questionnaire (MLwHFQ) was evaluated on Correlation between MLwHFQ score and SF-36 domains (r = -0.38 to -0.69). The Minnesota Living with Heart Failure Questionnaire score correlated with most SF-36 domains (r=-0.38 to -0.69), depressive symptoms, physical activity, and systolic function.
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