Key result
Severe mitral regurgitation was associated with significantly greater dynamic changes in mitral annular area throughout the cardiac cycle compared to controls (2.59 vs 1.98 cm2, p<0.001).
Why the study?
The study investigated mitral valve annular geometry changes during the cardiac cycle in patients with severe MR undergoing preprocedural CCTA before percutaneous mitral valve replacement or annuloplasty.
Observational (n=72)
Single-blind
No
Absolute Event Rate: 2.59% vs 1.98%
p-value: p=<0.001
In patients with severe mitral regurgitation, the mitral annulus undergoes significant dynamic changes during the cardiac cycle, typically reaching its largest dimension in systole, which has implications for pre-procedural planning of percutaneous interventions.
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CCTA multiphase assessment of dynamic annular changes may aid preprocedural planning in severe MR; leaves open whether systolic maxima affect device selection or outcomes.
Palmisano et al. (2021) conducted an observational in Severe mitral regurgitation (n=72). Severe mitral regurgitation vs. Patients without mitral regurgitation (severe aortic stenosis controls) was evaluated on Difference between maximum and minimum mitral annular area during the cardiac cycle (p=<0.001). Severe mitral regurgitation was associated with significantly greater dynamic changes in mitral annular area throughout the cardiac cycle compared to controls (2.59 vs 1.98 cm2, p<0.001).
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