Key result
Blood collection and handling techniques, including anticoagulant choice (e.g., heparin 20.1% vs EDTA 9.5%, P<0.0001) and collection method, significantly affect platelet-monocyte aggregation.
Population
Whole blood samples
Comparison
Various blood collection, handling, and… vs Comparisons between different collection…
Design
Preclinical
Authors
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Pre-analytical standardization is essential for reliable assays; leaves open clinical utility pending validation studies.
p-value: p=<0.0001
Measurement of platelet-monocyte aggregates is highly sensitive to pre-analytical variables, requiring standardized collection by direct venepuncture, use of a direct thrombin inhibitor, and minimal processing delay.
Din et al. (2007) studied this question. Blood collection, handling and processing techniques vs. Different anticoagulants and collection methods was evaluated on Platelet-monocyte aggregation levels (p=<0.0001). Blood collection and handling techniques, including anticoagulant choice (e.g., heparin 20.1% vs EDTA 9.5%, P<0.0001) and collection method, significantly affect platelet-monocyte aggregation.
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