Key result
Analysis of 175 mumps virus isolates in Korea from 2007 to 2012 identified genotypes I, H, and F, with distinctive point mutations at putative neutralizing epitope sites compared to the Jeryl-Lynn strain.
Population
175 clinical specimens of mumps virus isolated in Korea between 2007 and 2012
Design
Other
Authors
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Epitope mismatches may contribute to breakthrough mumps; leaves open whether vaccine strains need updating.
Observational (n=175)
Korean mumps virus isolates from 2007-2012 belong to genotypes I, H, and F, and exhibit amino acid differences at putative neutralizing epitope sites compared to the Jeryl-Lynn vaccine strain, which may help explain mumps outbreaks despite high vaccination coverage.
Kim et al. (2016) conducted an observational in Mumps (n=175). Mumps virus (MuV) strains was evaluated on Genetic characteristics (genotypes and amino acid sequences). Analysis of 175 mumps virus isolates in Korea from 2007 to 2012 identified genotypes I, H, and F, with distinctive point mutations at putative neutralizing epitope sites compared to the Jeryl-Lynn strain.
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