Key result
Analysis of 175 mumps virus isolates in Korea from 2007 to 2012 identified genotypes I, H, and F, with distinctive point mutations at putative neutralizing epitope sites compared to the Jeryl-Lynn strain.
Observational (n=175)
Korean mumps virus isolates from 2007-2012 belong to genotypes I, H, and F, and exhibit amino acid differences at putative neutralizing epitope sites compared to the Jeryl-Lynn vaccine strain, which may help explain mumps outbreaks despite high vaccination coverage.
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Epitope mismatches may contribute to breakthrough mumps; leaves open whether vaccine strains need updating.
Mumps is a vaccine-preventable viral disease. Despite vaccine coverage of >95%, the incidence of mumps has increased in Korea since 2007. This study aimed to genetically characterize mumps virus (MuV) strains that circulated in Korea between 2007 and 2012 to determine the factors underlying mumps outbreaks. MuV was isolated from 175 clinical specimens between 2007 and 2012 in Korea. Upon analysis of the SH gene in Korean mumps virus isolates, three different genotypes were identified: I, H, and F. The MuV genotypes I and H co-circulated in Korea, and eight isolates of Korean genotype F were found within the same time period in 2008. An analysis of HN amino-acid sequence data showed that Korean isolates had no changes in their glycosylation sites. At putative neutralizing epitope sites, the Jeryl-Lynn strain showed 4-5 different amino acid sequences from those observed in Korean isolates. Korean isolates of genotypes I and H shared distinctive point mutations on putative neutralizing epitope positions in each genotype. This report describes the genetic characteristics of MuV strains circulating in Korea and provides information on endemic mumps infections. This information may be important to help prevent mumps and control outbreaks of mumps in Korea. J. Med. Virol. 88:1479-1486, 2016.
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Kim et al. (2016) conducted an observational in Mumps (n=175). Mumps virus (MuV) strains was evaluated on Genetic characteristics (genotypes and amino acid sequences). Analysis of 175 mumps virus isolates in Korea from 2007 to 2012 identified genotypes I, H, and F, with distinctive point mutations at putative neutralizing epitope sites compared to the Jeryl-Lynn strain.
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