Key result
Fawn-hooded rats exhibited 2-4 times higher urinary excretion of TxB2, 6-keto-PgF1 alpha, and PgE2 compared to Wistar rats at 12 and 24 weeks.
Population
Male fawn-hooded (FH) rats and Wistar (WAG) rats
Comparison
Observation during normal ageing vs Wistar (WAG) rats
Design
Preclinical
Follow-up
60 weeks after weaning
Authors
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Animal data link eicosanoids to hyperfiltration; leaves open any role in human proteinuria progression.
In a spontaneous rat model of hyperfiltration and proteinuria, early hyperfiltration coincides with enhanced eicosanoid excretion, followed by a shift towards vasoconstrictor eicosanoids as proteinuria progresses.
Keijzer et al. (2008) studied Hyperfiltration and proteinuria. Fawn-hooded (FH) strain vs. Wistar (WAG) rats was evaluated on Urinary excretion of TxB2, 6-keto-PgF1 alpha and PgE2. Fawn-hooded rats exhibited 2-4 times higher urinary excretion of TxB2, 6-keto-PgF1 alpha, and PgE2 compared to Wistar rats at 12 and 24 weeks.
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