Key result
ACE I/D and AGT M235T polymorphisms were significantly associated with overweight-obesity, waist circumference, and BMI (p⩽0.001), with the I and M alleles linked to lower BMI.
Why the study?
It was unknown whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and BMI in a Tunisian population.
Are genetic variants in ACE I/D and AGT M235T associated with overweight-obesity and BMI in a Tunisian population?
Case-Control (n=628)
Are genetic variants in ACE I/D and AGT M235T associated with overweight-obesity and BMI in a Tunisian population?
p-value: p=⩽0.001
Variations in ACE I/D and AGT M235T polymorphisms are significantly associated with overweight-obesity, BMI, and dyslipidemia in a Tunisian population.
Observational associations should not guide obesity screening; leaves open causal roles for ACE/AGT variants in North African cohorts.
OBJECTIVE: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. METHODS: We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calculated. A total of 259 overweight-obese patients and 369 healthy controls were genotyped for the ACE I/D and AGT M235T genes using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: ACE I/D and AGT M235T genes were associated with BMI, waist circumference and overweight-obesity (p⩽0.001). In an additive model, the I and the M alleles in ACE and AGT variants, respectively, were associated with a lower BMI: -1.45 and -2.29 units, respectively. ACE I/D genotypes were associated with dyslipidemia; AGT M235T genotypes with dyslipidemia and total cholesterol. CONCLUSION: These data suggest that variations in ACE I/D and AGT M235T affect the risk of overweight-obesity, BMI and dyslipidemia, and could point to a key molecular pathway of metabolic syndrome and its related comorbidities.
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Khamlaoui et al. (2020) conducted a case-control in Overweight-obesity (n=628). ACE I/D and AGT M235T polymorphisms vs. Healthy controls was evaluated on BMI, waist circumference and overweight-obesity (p=⩽0.001). ACE I/D and AGT M235T polymorphisms were significantly associated with overweight-obesity, waist circumference, and BMI (p⩽0.001), with the I and M alleles linked to lower BMI.
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