Key result
Comprehensive multiorgan system and functional phenotyping of preclinical models is essential to discover and validate novel targets for HFpEF therapeutic development.
Comprehensive multiorgan system and functional phenotyping of preclinical models is proposed as essential for discovering novel targets for HFpEF.
T he lack of effective treatments for heart failure with preserved ejection fraction represents a large and growing unmet need in cardiology today.A critical obstacle to therapeutic innovation in heart failure with preserved ejection fraction has been the absence of animal models that accurately recapitulate the complexities of the human disease.Here, we propose that more comprehensive multiorgan system and functional phenotyping of preclinical models is essential if we are to maximize our chances of discovering and validating novel targets for effective therapeutic development in heart failure with preserved ejection fraction.Why Don't We Have Proven Treatments for HFpEF?
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Roh et al. (2017) conducted an editorial in Heart failure with preserved ejection fraction (HFpEF). Comprehensive multiorgan system and functional phenotyping of preclinical models was evaluated. Comprehensive multiorgan system and functional phenotyping of preclinical models is essential to discover and validate novel targets for HFpEF therapeutic development.
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