Key result
Poliomyelitis virus is rapidly inactivated at low stomach pH during digestion, but escapes inactivation in the higher pH of the intestine, providing conditions for intestinal entry of infection.
Population
Poliomyelitis virus exposed to gastric and intestinal digestion conditions
Design
Preclinical
Authors
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Suggests pH-dependent intestinal entry in animal models; hypothesis-generating and should not yet inform human prevention strategies.
Poliomyelitis virus can survive gastric transit and remain active in the alkaline environment of the intestine, facilitating intestinal infection.
Faber et al. (1946) studied Poliomyelitis virus infection. Gastric and intestinal digestion (pH levels, pepsin, trypsin) was evaluated on Inactivation of poliomyelitis virus. Poliomyelitis virus is rapidly inactivated at low stomach pH during digestion, but escapes inactivation in the higher pH of the intestine, providing conditions for intestinal entry of infection.
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