Key result
Double-crosslinked bioprosthetic valve leaflets (SAP + Que-PP) demonstrated excellent anticoagulant, antithrombotic, anti-inflammatory, and anti-calcification properties in preclinical models.
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Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets demonstrate improved hemocompatibility, anti-inflammatory, and anti-calcification properties, showing potential as an alternative to traditional GA-crosslinked valves.
assay manifested that the double-crosslinked BVLs had excellent anticoagulant and antithrombotic properties, owing to the introduction of SAP. The subcutaneous implantation also demonstrated that the obtained BVLs showed a reduced inflammatory response and great resistance to calcification, which is attributed to quercetin with multiple physiological activities and depletion of aldehyde groups by hydroxyl aldehyde reaction. With excellent stability, hemocompatibility, anti-inflammatory, anti-calcification, and pro-endothelialization properties, the obtained double-crosslinked BVLs, SAP + Que-PP, would have great potential to substitute the current clinical GA-crosslinked BVLs.
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Hu et al. (2022) studied this question. Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets (SAP + Que-PP) vs. GA-crosslinked BVLs was evaluated on Anticoagulant, antithrombotic properties, inflammatory response, and calcification. Double-crosslinked bioprosthetic valve leaflets (SAP + Que-PP) demonstrated excellent anticoagulant, antithrombotic, anti-inflammatory, and anti-calcification properties in preclinical models.
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