What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hepatitis A Virus (HAV) infection (n=4030). Intervention: Birth before 1945 vs. Birth since 1975. Primary outcome: Antibody to HAV (anti-HAV) positivity.

October 1, 1993The Journal of Infectious Diseases

Secular Trends in Hepatitis A Virus Infection among Alaska Natives

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Key result

Past HAV infection was strongly age-related among Alaska Natives, with anti-HAV prevalence increasing from 7% in persons born since 1975 to 85% among those born before 1945.

Population

4030 Alaska Natives statewide, selected by random sample stratified by year of birth and community of…

Design

Cross-sectional

Authors

LBL. R. BulkowCenters for Disease Control and Prevention RWRobert B. WainwrightCenters for Disease Control and Prevention BMBrian J. McMahonAlaska Native Tribal Health Consortium

Discussion

Member takes

Implication

Supports targeted HAV vaccination in young Alaska Natives; leaves open whether age-stratified seroprevalence predicts outbreaks in other populations.

Study Design

Type

Cross-Sectional (n=4,030)

Multicenter

Yes

Structured PICO

Population

4,030 Alaska Natives selected statewide to assess the prevalence and epidemiologic characteristics of past Hepatitis A virus infection.

Outcome

Prevalence of antibody to hepatitis A virus (anti-HAV)

Main Result

Absolute Event Rate: 85% vs 7%

Hepatitis A infection among Alaska Natives has historically occurred in village-wide outbreaks, suggesting widespread vaccination of young susceptible populations could prevent future epidemics.

Cite This Study

Bulkow et al. (1993) conducted a cross-sectional in Hepatitis A Virus (HAV) infection (n=4,030). Birth before 1945 vs. Birth since 1975 was evaluated on Antibody to HAV (anti-HAV) positivity. Past HAV infection was strongly age-related among Alaska Natives, with anti-HAV prevalence increasing from 7% in persons born since 1975 to 85% among those born before 1945.

synapsesocial.com/papers/6a9feea683b4417cc5efd83e https://doi.org/10.1093/infdis/168.4.1017

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October 1, 1993The Journal of Infectious Diseases

Secular Trends in Hepatitis A Virus Infection among Alaska Natives

View Full Paper

Ask AI

Bookmark

Key result

Past HAV infection was strongly age-related among Alaska Natives, with anti-HAV prevalence increasing from 7% in persons born since 1975 to 85% among those born before 1945.

Population

4030 Alaska Natives statewide, selected by random sample stratified by year of birth and community of…

Design

Cross-sectional

Authors

LBL. R. BulkowCenters for Disease Control and Prevention RWRobert B. WainwrightCenters for Disease Control and Prevention BMBrian J. McMahonAlaska Native Tribal Health Consortium

Discussion

Member takes

Implication

Supports targeted HAV vaccination in young Alaska Natives; leaves open whether age-stratified seroprevalence predicts outbreaks in other populations.

Study Design

Type

Cross-Sectional (n=4,030)

Multicenter

Yes

Structured PICO

Population

4,030 Alaska Natives selected statewide to assess the prevalence and epidemiologic characteristics of past Hepatitis A virus infection.

Outcome

Prevalence of antibody to hepatitis A virus (anti-HAV)

Main Result

Absolute Event Rate: 85% vs 7%

Hepatitis A infection among Alaska Natives has historically occurred in village-wide outbreaks, suggesting widespread vaccination of young susceptible populations could prevent future epidemics.

Cite This Study

synapsesocial.com/papers/6a9feea683b4417cc5efd83e https://doi.org/10.1093/infdis/168.4.1017

Also Consider

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