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April 7, 2011Journal of Hypertension

Benefit assessment of salt reduction in patients with hypertension: systematic overview

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Key result

Reduced salt intake in hypertensive patients lowered mean systolic blood pressure by 3.6-8.0 mmHg over up to 12 months, though benefits for patient-relevant outcomes remain unproven.

Why the study?

Does reduced salt intake improve patient-relevant outcomes and lower blood pressure in patients with essential hypertension?

Population

Patients with essential hypertension

Design

Systematic_review

Follow-up

up to 12 months

Authors

EMEva MatyasMedical University of GrazKJKlaus JeitlerMedical University of GrazKHKarl HorvathUniversity of Graz

Discussion

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Member takes

Overview

Supports salt reduction for BP management in hypertension; leaves open effects on hard clinical outcomes.

Study Design

Type

Systematic Review

Structured PICO

Does reduced salt intake improve patient-relevant outcomes and lower blood pressure in patients with essential hypertension?

P
Population
Patients with essential hypertension assessed for the effects of reduced salt intake over up to 12 months.
I
Intervention
Reduced salt intake
O
Outcome
Patient-relevant outcomes (death, cardiovascular morbidity/mortality, hospital stays, terminal renal failure, quality of life, and adverse events) and change in blood pressurehard clinical

Main Result

Effect estimate: SBP reduction of 3.6-8.0 mmHg

While reduced salt intake effectively lowers blood pressure in patients with essential hypertension, there is a lack of high-quality evidence demonstrating a reduction in hard clinical outcomes.

Limitations

  • Only one review reported limited data on patient-relevant outcomes
  • None of the RCTs identified in the primary literature search update reported data on patient-relevant outcomes

Cite This Study

Matyas et al. (2011) conducted a systematic review in essential hypertension. Reduced salt intake was evaluated on Patient-relevant outcomes and blood pressure (SBP reduction of 3.6-8.0 mmHg). Reduced salt intake in hypertensive patients lowered mean systolic blood pressure by 3.6-8.0 mmHg over up to 12 months, though benefits for patient-relevant outcomes remain unproven.

synapsesocial.com/papers/6aa00b5f3579a0ffc99ca286https://doi.org/10.1097/hjh.0b013e3283442840

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1How Far Should Salt Intake Be Reduced?2003 · 389 citations
  2. 2Blood Pressure Reduction and Cardiovascular Prevention: An Update Including the 2003-2004 Secondary Prevention Trials2005 · 247 citations
  3. 3Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations1996 · 862 citations
  4. 4FAILURE OF THERAPY TO IMPROVE PROGNOSIS IN ELDERLY MALES WITH HYPERTENSION1980 · 86 citations
  5. 5Effects of intensified antihypertensive treatment in diabetic nephropathy1999 · 44 citations