Key result
Kv1.1 is expressed by interstitial cells of Cajal across several species, and its outward current is specifically blocked by the mamba snake toxin dendrotoxin-K (EC50 = 0.34 nM).
Effect estimate: EC50 = 0.34 nM
Kv1.1 is expressed by interstitial cells of Cajal across several species and can be specifically blocked by DTX-K, providing a tool for identifying ICC and studying their delayed rectifier K+ currents.
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Provides selective ICC probe in animal models; leaves open translation to human GI motility disorders.
Hatton et al. (2001) studied this question. Dendrotoxin-K (DTX-K) was evaluated on Kv1.1 outward current block (EC50 = 0.34 nM). Kv1.1 is expressed by interstitial cells of Cajal across several species, and its outward current is specifically blocked by the mamba snake toxin dendrotoxin-K (EC50 = 0.34 nM).
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