Key result
Kv2.2 is expressed in gastrointestinal smooth muscle cells and its expression in Xenopus oocytes results in a slowly activating K+ current inhibited by tetraethylammonium, 4-aminopyridine, and quinine.
Population
Human and canine colonic circular smooth muscle-derived mRNA, canine gastrointestinal tract and vascular…
Design
Preclinical
Authors
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Kv2.2 expression in GI smooth muscle may modulate contractility; leaves open functional and therapeutic roles in humans.
Kv2.2 is expressed in gastrointestinal smooth muscle and likely contributes to the slow component of the delayed rectifier K+ current in native colonic myocytes.
Schmalz et al. (1998) studied this question. Kv2.2 mRNA injection was evaluated on Expression of a slowly activating K+ current. Kv2.2 is expressed in gastrointestinal smooth muscle cells and its expression in Xenopus oocytes results in a slowly activating K+ current inhibited by tetraethylammonium, 4-aminopyridine, and quinine.
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