Key result
Kv2.1 channels contribute significantly to the delayed rectifier current in rabbit urethral smooth muscle cells, and their blockade prolongs action potentials when BK channels are inhibited.
Kv2.1 channels contribute significantly to the delayed rectifier K+ current in rabbit urethral smooth muscle cells, modulating action potential duration when BK channels are blocked.
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No immediate clinical implications for urethral function; leaves open Kv2 channel relevance in human smooth muscle.
Kyle et al. (2011) studied Normal physiology (rabbit urethra). Stromatoxin-1 (ScTx) vs. Control (absence of ScTx) was evaluated on Kv current amplitude and action potential duration. Kv2.1 channels contribute significantly to the delayed rectifier current in rabbit urethral smooth muscle cells, and their blockade prolongs action potentials when BK channels are inhibited.
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