Key result
Both Ca(2+)-activated and voltage-dependent K(+) currents were identified in sheep urethral myocytes, contributing to slow waves and likely influencing urethral tone.
Both Ca(2+)-activated and voltage-dependent K(+) currents are present in sheep urethral myocytes and contribute to slow waves, suggesting they influence urethral tone.
No takes yet. Share an insight, caveat, or question.
No direct clinical implications yet; leaves open whether K+ currents modulate human urethral tone.
Hollywood et al. (2000) studied Isolated smooth muscle cells from sheep urethra. Ion channel blockers (iberiotoxin, penitrem A, nifedipine, TEA) was evaluated on Membrane currents (transient outward and sustained currents). Both Ca(2+)-activated and voltage-dependent K(+) currents were identified in sheep urethral myocytes, contributing to slow waves and likely influencing urethral tone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: