Key result
Nifedipine reduced CTA2-induced coronary vasoconstriction by 65% at 100 ng/ml (P<0.01) and 75% at 1,000 ng/ml (P<0.005), indicating thromboxane vasoconstriction depends on inward calcium flux.
The mechanism of thromboxane-induced coronary vasoconstriction relies on an inward calcium flux, explaining the efficacy of calcium antagonists in treating coronary vasospasm.
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May support calcium antagonists in vasospasm; leaves open translation of thromboxane-calcium mechanism from animal data.
Smith et al. (1981) studied Coronary vasoconstriction. Carbocyclic thromboxane A2 (CTA2) and calcium antagonists (e.g., nifedipine) was evaluated on Coronary vasoconstriction. Nifedipine reduced CTA2-induced coronary vasoconstriction by 65% at 100 ng/ml (P<0.01) and 75% at 1,000 ng/ml (P<0.005), indicating thromboxane vasoconstriction depends on inward calcium flux.
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