What is the clinical evidence from this study?

Study design: Other. Population: Healthy subjects. Intervention: Deltorphin. Primary outcome: Plasma catecholamine responses to insulin-induced hypoglycemia and cold pressor test.

What question did this study set out to answer?

To determine the regulatory role of delta-opioid receptors in the human sympathoadrenomedullary system during acute physical stress.

December 1, 1993The Journal of Clinical Endocrinology & Metabolism

Stress-induced activation of sympathetic nervous system is attenuated by the delta-opioid receptor agonist deltorphin in healthy man.

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Key result

Deltorphin completely suppressed norepinephrine elevation during insulin-induced hypoglycemia and blocked both norepinephrine and epinephrine release during cold pressor testing.

Why the study?

Does deltorphin attenuate plasma catecholamine responses to stress (insulin-induced hypoglycemia and cold pressor test) in healthy men?

Population

Healthy men (normal subjects)

Design

Other

Authors

EUEttore C. degli UbertiUniversity of Siena MAMaria Rosaria AmbrosioUniversity of Ferrara LVLuciana VergnaniUniversity of Ferrara

Discussion

Member takes

Implication

May blunt sympathetic reactivity in healthy volunteers; leaves open delta-opioid targeting for autonomic dysregulation in disease.

Key Points

To determine the regulatory role of delta-opioid receptors in the human sympathoadrenomedullary system during acute physical stress.
Assessed plasma catecholamine concentrations in healthy subjects across two separate experimental stress protocols.
Administered the selective delta-opioid receptor agonist deltorphin alongside insulin-induced hypoglycemia and the cold pressor test to measure catecholamine reactivity.
Deltorphin did not alter basal plasma levels of norepinephrine or epinephrine.
Deltorphin completely suppressed the insulin-induced hypoglycemia-evoked rise in norepinephrine and reduced the epinephrine response by 20%, though the epinephrine decrease was not statistically significant.
Deltorphin completely blocked the release of both norepinephrine and epinephrine provoked by the cold pressor test.

Structured PICO

Does deltorphin attenuate plasma catecholamine responses to stress (insulin-induced hypoglycemia and cold pressor test) in healthy men?

Population

Normal subjects evaluated for plasma catecholamine responses to insulin-induced hypoglycemia and cold pressor test.

Intervention

Deltorphin (DT), a highly selective delta-opioid receptor agonist

Outcome

Plasma catecholamine (norepinephrine and epinephrine) responses to insulin-induced hypoglycemia (IIH) and cold pressor test (CPT)surrogate

Specific delta-opioid receptor stimulation with deltorphin exerts an inhibitory effect on stress-induced norepinephrine release, suggesting delta-opioid receptors influence autonomic sympathetic reactivity.

Cite This Study

Uberti et al. (1993) studied Healthy subjects. Deltorphin was evaluated on Plasma catecholamine responses to insulin-induced hypoglycemia and cold pressor test. Deltorphin completely suppressed norepinephrine elevation during insulin-induced hypoglycemia and blocked both norepinephrine and epinephrine release during cold pressor testing.

synapsesocial.com/papers/6aa03aa01b05488b5fc727e9 https://doi.org/10.1210/jcem.77.6.8263131

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Stress-induced activation of sympathetic nervous system is attenuated by the delta-opioid receptor agonist deltorphin in healthy man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Stress-induced activation of sympathetic nervous system is attenuated by the delta-opioid receptor agonist deltorphin in healthy man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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