September 1, 1985Clinical Science
Enhancement of the sympathoadrenal response to the cold-pressor test by naloxone in man
Why the study?
Does naloxone pretreatment enhance the sympathoadrenal response to a cold-pressor test in normal male subjects?
Population
6 normal male subjects
Comparison
Naloxone pretreatment prior to a standard… vs Standard cold-pressor test without naloxone
Design
Other
Authors
Discussion
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Member takes
Implication
Suggests endogenous opioids blunt sympathoadrenal responses to acute stress; hypothesis-generating with no immediate clinical implications.
Structured PICO
Does naloxone pretreatment enhance the sympathoadrenal response to a cold-pressor test in normal male subjects?
P
Population
6 normal male subjects
I
Intervention
Naloxone (8 mg) pretreatment prior to a standard cold-pressor test
C
Comparator
Standard cold-pressor test without naloxone (implied baseline/control)
O
Outcome
Plasma catecholamine (noradrenaline and adrenaline) and pressor (systolic blood pressure and heart rate) responsesurrogate
Naloxone enhances the sympathoadrenal response to acute cold stress, suggesting that endogenous opioids are involved in the physiological response to mild acute stress in humans.
Cite This Study
Bouloux et al. (1985) studied this question.