Key result
Reducing mitochondrial aerobic capacity with oligomycin increased the response time of oxidative phosphorylation to heart rate steps by 34-40%, much less than the 100% predicted by feedback control.
p-value: p=< 0.05
The dynamic regulation of cardiac oxidative phosphorylation cannot be explained by simple immediate feedback control via diffusing ADP and Pi.
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Challenges feedback-only models of cardiac OXPHOS regulation; leaves open identification of dynamic control mechanisms in vivo.
Beek et al. (1999) studied this question. Reducing mitochondrial aerobic capacity with oligomycin vs. Baseline (before reducing MAC) was evaluated on Response time of oxidative phosphorylation (t(mito)) to heart rate steps (p=< 0.05). Reducing mitochondrial aerobic capacity with oligomycin increased the response time of oxidative phosphorylation to heart rate steps by 34-40%, much less than the 100% predicted by feedback control.
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