Key result
At 300 mumol/L, octanol and heptanol decreased triggered propagated contraction force to 21.3% and 25.7%, and propagation velocity to 15.4% and 13.0% in rat cardiac trabeculae.
Gap junction blockers octanol and heptanol dose-dependently decrease the force, propagation velocity, and triggering rate of damage-induced contractions in rat cardiac trabeculae, supporting the role of cell-to-cell calcium diffusion in this process.
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Supports gap junction role in triggered contractions; hypothesis-generating, requires human validation before any clinical consideration.
Zhang et al. (1996) studied this question. Octanol and heptanol was evaluated on Force, propagation velocity, and triggering rate of triggered propagated contractions (TPCs). At 300 mumol/L, octanol and heptanol decreased triggered propagated contraction force to 21.3% and 25.7%, and propagation velocity to 15.4% and 13.0% in rat cardiac trabeculae.
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