Key result
Final childhood GH growth velocity positively correlates with adult IGF-I z-score increases during subsequent therapy.
Why the study?
Does the response to growth hormone treatment during childhood correlate with the response during adulthood in patients with childhood-onset GH deficiency?
Cohort (n=47)
No
Does the response to growth hormone treatment during childhood correlate with the response during adulthood in patients with childhood-onset GH deficiency?
Final growth velocity during childhood GH treatment may predict future IGF-I response to GH treatment in adulthood for patients with childhood-onset GH deficiency.
Answers are grounded in this paper and cite their sources.
Final childhood GH velocity may predict adult IGF-I response in GHD; leaves open whether it guides adult dosing or monitoring.
Our aim was to analyze a cohort of patients with childhood-onset growth hormone deficiency (GHD) to evaluate if there is some correlation between the response to GH treatment during childhood and adulthood, respectively. This was an observational retrospective monocentric cohort study of 47 patients treated with GH during childhood and adulthood. Changes in growth parameters during childhood were compared with the increase of IGF-I z-score and other indexes of GH response (body composition, lipid profile) after 1 year of treatment in adulthood. The only significant positive correlation was observed between final growth velocity during the last year of childhood GH treatment and increase in IGF-I z-score in GH-treated adults (r=0.592, p=< 0.01). No correlation was observed between growth-promoting effects of GH as child and metabolic changes induced by GH as adult. We also observed a negative correlation between weight at the end of childhood GH treatment and the IGF-I response during first year of treatment in adults (r=- 0.335, p <0.05). No significant positive correlation could be observed between the main parameters that evaluate response to GH treatment in children and adults. However, the final growth velocity, which may be considered as one of the main criteria of end of GH treatment in children, was identified as parameter that could predict future response to GH treatment in adulthood.
No takes yet. Share an insight, caveat, or question.
Thilmany et al. (2018) conducted a cohort in Childhood-onset growth hormone deficiency (GHD) (n=47). Growth Hormone (GH) treatment was evaluated on Correlation between changes in growth parameters during childhood and increase of IGF-I z-score and other indexes of GH response after 1 year of treatment in adulthood (r=0.592, p=<0.01). Final growth velocity during the last year of childhood GH treatment positively correlated with the increase in IGF-I z-score after 1 year of GH treatment in adulthood (r=0.592, p<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: