Key result
Women and elderly patients derive similar benefit to younger males from evidence-based treatments for ischaemic heart disease and heart failure, despite being under-represented in clinical trials.
Why the study?
Do women and elderly patients with cardiovascular disease derive similar benefit from evidence-based treatments compared to younger males?
Do women and elderly patients with cardiovascular disease derive similar benefit from evidence-based treatments compared to younger males?
Despite under-representation in clinical trials, women and elderly patients should receive the same evidence-based cardiovascular treatments as younger males.
Answers are grounded in this paper and cite their sources.
Supports equitable use of evidence-based therapies in women and elderly; leaves open need for dedicated trials to confirm generalizability.
PURPOSE OF REVIEW: Women and older patients with cardiovascular disease are frequently underinvestigated and are less likely to receive evidence-based treatments than younger male counterparts. A lack of sex and age-specific clinical trial evidence is frequently cited for this practice. This manuscript reviews the currently available evidence base in the management of both groups presenting with ischaemic heart disease and heart failure. RECENT FINDINGS: Registry data in both women and older patients confirm that these groups receive suboptimal care in the management of ischaemic heart disease and heart failure. A number of recent trials, including several meta-analyses, do not support this practice and suggest that, with the possible exception of implantable cardiac defibrillator implantation in females, both women and elderly patients derive similar benefit to younger males in the management of risk factors, symptomatic ischaemic heart disease and heart failure. SUMMARY: Pending sex and age-specific trials to address in particular not only outcomes but dosing and complications, women and elderly patients should receive similar evidence-based treatment of cardiac risk factors, symptomatic ischaemic disease and heart failure to younger males.
No takes yet. Share an insight, caveat, or question.
Gerard Devlin (2010) conducted a review in Ischaemic heart disease and heart failure. Evidence-based treatments vs. Younger males was evaluated. Women and elderly patients derive similar benefit to younger males from evidence-based treatments for ischaemic heart disease and heart failure, despite being under-represented in clinical trials.
Synapse has enriched 10 related papers. Consider them for comparative context: