Key result
Combined high angiopoietin-like 4 and tenascin-C expression predicts worse survival in tongue cancer.
Why the study?
Does the expression level of angiopoietin-like 4, tenascin-C, and cathepsin-C predict prognosis in patients with oral tongue squamous cell carcinoma?
Population
158 cases of paraffin-embedded tongue cancer
Comparison
Measurement of angiopoietin-like 4, tenascin-C… vs Low expression levels of the respective genes
Design
Cohort
Authors
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May refine tongue cancer prognostication; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=158)
Does the expression level of angiopoietin-like 4, tenascin-C, and cathepsin-C predict prognosis in patients with oral tongue squamous cell carcinoma?
p-value: p=0.001
High mRNA expression of angiopoietin-like 4 and tenascin-C in paraffin-embedded tissues serves as an independent predictor of poor survival in tongue cancer.
Wang et al. (2010) conducted a cohort in oral tongue squamous cell carcinoma (n=158). High expression of angiopoietin-like 4 and tenascin-C was evaluated on poor prognosis / survival (p=0.001). Concomitant high expression of angiopoietin-like 4 and tenascin-C was an independent predictor of poor survival in patients with tongue cancer (p=0.001).
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