Myocardial asynchronism is a determinant of changes in functional mitral regurgitation severity during dynamic exercise in patients with chronic heart failure due to severe left ventricular systolic dysfunction
Key result
Resting left ventricular asynchronism significantly correlated with worsening functional mitral regurgitation during dynamic exercise in patients with chronic heart failure (r=0.66, P<0.0001).
Why the study?
Does resting LV asynchronism correlate with changes in functional mitral regurgitation severity during dynamic exercise in patients with HFrEF?
Population
70 patients with chronic heart failure due to left ventricular systolic dysfunction and functional mitral…
Comparison
Maximal symptom-limited dynamic exercise test… vs Resting state
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports hypothesis that resting asynchronism contributes to dynamic MR in HFrEF; leaves open whether resynchronization improves exercise hemodynamics.
Study Design
Type
Observational (n=70)
Structured PICO
Does resting LV asynchronism correlate with changes in functional mitral regurgitation severity during dynamic exercise in patients with HFrEF?
P
Population
70 patients with chronic heart failure due to left ventricular systolic dysfunction (LVEF <40%) and functional mitral regurgitation in sinus rhythm.
E
Exposure
Maximal symptom-limited dynamic exercise test with continuous 2D-Doppler echocardiography
C
Comparator
Resting state
O
Outcome
Changes in mitral regurgitant volume (RV) and effective regurgitant orifice (ERO) during exercise and their correlation with LV asynchronismsurrogate
Main Result
Effect estimate: r=0.66
p-value: p=<0.0001
Resting left ventricular asynchronism is a significant determinant of worsening functional mitral regurgitation during dynamic exercise in patients with HFrEF.
Cite This Study
Ennezat et al. (2005) conducted an observational in Chronic heart failure due to severe left ventricular systolic dysfunction (n=70). Left ventricular asynchronism at rest was evaluated on Changes in mitral effective regurgitant orifice (ERO) and regurgitant volume (RV) during dynamic exercise (r=0.66, p=<0.0001). Resting left ventricular asynchronism significantly correlated with worsening functional mitral regurgitation during dynamic exercise in patients with chronic heart failure (r=0.66, P<0.0001).