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A comparison of second-order rate constants for reactions of 2-bromo-1-phenylethanone (phenacyl bromide) and methyl iodide with various nucleophiles in acetonitrile at 25·0 °C reveals that the rate enhancement due to the carbonyl group in the position adjacent to the reacting carbon atom in alkyl halides is not a general effect but is very dependent upon the nucleophile.
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Halvorsen et al. (1978) studied this question.
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