Key result
Chronic sildenafil linked to ~4.5 mmHg lower transpulmonary gradient and lower PVR in pre-transplant HF.
Why the study?
Does chronic sildenafil administration improve transpulmonary gradient, pulmonary vascular resistance, and cardiac output in heart failure patients awaiting heart transplantation?
Population
6 patients with heart failure awaiting heart transplantation, with elevated pulmonary vascular resistance…
Design
Case_series
Follow-up
average 68+/-58 days (range 4-145 days)
Authors
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May improve transplant eligibility in select advanced HF cases; leaves open confirmation in prospective trials.
Observational (n=6)
Does chronic sildenafil administration improve transpulmonary gradient, pulmonary vascular resistance, and cardiac output in heart failure patients awaiting heart transplantation?
Chronic sildenafil administration safely improves pulmonary hemodynamics in heart failure patients, potentially allowing those with elevated pulmonary vascular resistance to become eligible for heart transplantation.
Jabbour et al. (2007) conducted an observational in Heart failure awaiting heart transplantation (n=6). Chronic sildenafil was evaluated on Transpulmonary gradient (TPG), pulmonary vascular resistance (PVR), and cardiac output (CO). Chronic sildenafil administration reduced average transpulmonary gradient by 4.5 mmHg and pulmonary vascular resistance by 167 dyn s cm(-5) in heart failure patients awaiting transplantation.
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