Key result
Patients with scleroderma exhibited depressed global left ventricular function, biventricular diastolic abnormalities, and impaired longitudinal muscle function compared to healthy volunteers.
Why the study?
Are left and right ventricular functions impaired in patients with scleroderma compared to healthy volunteers?
Case-Control (n=44)
Are left and right ventricular functions impaired in patients with scleroderma compared to healthy volunteers?
Tissue Doppler echocardiography reveals subclinical biventricular diastolic dysfunction and depressed longitudinal muscle function in patients with scleroderma.
May prompt earlier cardiac evaluation in scleroderma; leaves open whether dysfunction predicts events or warrants intervention.
In this study, left and right ventricular functions were examined echocardiographically in 22 patients with scleroderma and 22 healthy volunteers. Conventional and tissue Doppler echocardiography and myocardial performance indexes were used as measures of right and left ventricular global functions. Mitral early diastolic E wave deceleration time, isovolumetric contraction time and left ventricular myocardial performance index and peak tricuspid A wave velocity were significantly higher in the scleroderma group compared with the control group. Mitral and tricuspid E/A ratios were significantly lower in patients with scleroderma. In addition, mitral annular and tricuspid annular isovolumetric relaxation times and the tricuspid E/E' ratio were significantly increased in scleroderma patients compared with the control group. In conclusion, in scleroderma patients the global left ventricular functions were depressed and diastolic function abnormalities were seen in both right and left ventricles. In addition, longitudinal muscle functions of the ventricles were depressed in scleroderma patients, as shown by tissue Doppler imaging parameters.
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Güllülü et al. (2005) conducted a case-control in Scleroderma (n=44). Scleroderma vs. Healthy volunteers was evaluated on Echocardiographic measures of right and left ventricular global functions. Patients with scleroderma exhibited depressed global left ventricular function, biventricular diastolic abnormalities, and impaired longitudinal muscle function compared to healthy volunteers.
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