Key result
Ca2+ and AMPOPCP increase mutual binding affinity via positive cooperativity in bullfrog skeletal muscle sarcoplasmic reticulum.
Population
Fragmented sarcoplasmic reticulum (FSR) from bullfrog skeletal muscle and rabbit skeletal muscle
Design
Preclinical
Authors
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Caution against clinical extrapolation from bullfrog skeletal SR; leaves open species-specific cooperativity in mammalian cardiac models.
Demonstrates a positive cooperative interaction between Ca2+ and ATP analogue binding to sarcoplasmic reticulum in bullfrog skeletal muscle, contrasting with negative cooperativity in rabbit muscle.
Ogawa et al. (1986) studied this question. Ca2+ and AMPOPCP was evaluated on Binding to fragmented sarcoplasmic reticulum. Ca2+ and AMPOPCP bind to bullfrog skeletal muscle fragmented sarcoplasmic reticulum with positive cooperative interaction, increasing each other's binding affinity.
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