March 17, 2022Frontiers in Cardiovascular MedicineOpen Access

High moderate-to-vigorous physical activity linked to ~44% lower cardiocerebrovascular mortality vs inactivity in hypertension.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertension (n=4917). Intervention: High moderate-to-vigorous physical activity (≥7.5 MET-h/week) vs. Physical inactivity (0 MET-h/week). Primary outcome: Cardiocerebrovascular mortality (HR 0.56, 95% CI 0.41-0.77, p=<0.001).

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Why the study?

The effect of different levels of leisure-time moderate-to-vigorous physical activity against cardiocerebrovascular and all-cause mortality in hypertension was unclear.

Does moderate-to-vigorous physical activity reduce cardiocerebrovascular and all-cause mortality in adult patients with hypertension?

Population

NHANES participants with hypertension from 1999 to 2006

Comparison

Inactive vs low-active vs high-active MV-PA

Design

Cohort study

Follow-up

Median 10.93-year

Key result

High levels of moderate-to-vigorous physical activity (≥7.5 MET-h/week) significantly reduced the risk of cardiocerebrovascular mortality by 44% (HR 0.56) compared to physical inactivity in patients with hypertension.

Authors

JXJun‐Peng Xu RZRui‐Xiang Zeng HLHaining Lu

Discussion

Member takes

Overview

May support 7.5–15 MET-h/wk MV-PA for lowest mortality in hypertension; leaves open causality and optimal dosing in trials.

Study Design

Type

Cohort (n=4,917)

Structured PICO

Does moderate-to-vigorous physical activity reduce cardiocerebrovascular and all-cause mortality in adult patients with hypertension?

Population

4,917 adult patients with hypertension from the US NHANES cohort were followed for a median of 10.93 years to assess the impact of physical activity on mortality.

Exposure

Low-active (0 < to < 7.5 MET-h/week) and high-active (≥ 7.5 MET-h/week) leisure-time moderate-to-vigorous physical activity (MV-PA)

Comparator

Inactive (0 MET-h/week) leisure-time moderate-to-vigorous physical activity (MV-PA)

Outcome

Cardiocerebrovascular and all-cause mortalityhard clinical

Main Result

Hazard Ratio: 0.56 (95% CI 0.41–0.77)

Absolute Event Rate: 4.95% vs 13.85%

p-value: p=<0.001

In patients with hypertension, engaging in moderate-to-vigorous physical activity of 7.5 to < 15 MET-h/week is associated with the lowest risks of cardiocerebrovascular and all-cause mortality.

Limitations

Physical activity volume was self-reported via questionnaire, which may be subject to recall bias
Other sources of daily physical activity (e.g., work, household) were not included
Fluctuation of individual physical activity volume during follow-up was not considered
Causes of hypertension were unavailable, meaning secondary hypertension might be included
Observational design cannot establish a causal relationship

Cite This Study

Xu et al. (2022) conducted a cohort in Hypertension (n=4,917). High moderate-to-vigorous physical activity (≥7.5 MET-h/week) vs. Physical inactivity (0 MET-h/week) was evaluated on Cardiocerebrovascular mortality (HR 0.56, 95% CI 0.41-0.77, p=<0.001). High levels of moderate-to-vigorous physical activity (≥7.5 MET-h/week) significantly reduced the risk of cardiocerebrovascular mortality by 44% (HR 0.56) compared to physical inactivity in patients with hypertension.

synapsesocial.com/papers/6aa12ba925b16df109667975 https://doi.org/10.3389/fcvm.2022.844680

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March 17, 2022Frontiers in Cardiovascular MedicineOpen Access

High moderate-to-vigorous physical activity linked to ~44% lower cardiocerebrovascular mortality vs inactivity in hypertension.

View Full Paper

Ask AI

Bookmark

Why the study?

The effect of different levels of leisure-time moderate-to-vigorous physical activity against cardiocerebrovascular and all-cause mortality in hypertension was unclear.

Does moderate-to-vigorous physical activity reduce cardiocerebrovascular and all-cause mortality in adult patients with hypertension?

Population

NHANES participants with hypertension from 1999 to 2006

Comparison

Inactive vs low-active vs high-active MV-PA

Design

Cohort study

Follow-up

Median 10.93-year

Key result

Authors

JXJun‐Peng Xu RZRui‐Xiang Zeng HLHaining Lu

Discussion

Member takes

Overview

May support 7.5–15 MET-h/wk MV-PA for lowest mortality in hypertension; leaves open causality and optimal dosing in trials.

Study Design

Type

Cohort (n=4,917)

Structured PICO

Does moderate-to-vigorous physical activity reduce cardiocerebrovascular and all-cause mortality in adult patients with hypertension?

Population

4,917 adult patients with hypertension from the US NHANES cohort were followed for a median of 10.93 years to assess the impact of physical activity on mortality.

Exposure

Low-active (0 < to < 7.5 MET-h/week) and high-active (≥ 7.5 MET-h/week) leisure-time moderate-to-vigorous physical activity (MV-PA)

Comparator

Inactive (0 MET-h/week) leisure-time moderate-to-vigorous physical activity (MV-PA)

Outcome

Cardiocerebrovascular and all-cause mortalityhard clinical

Main Result

Hazard Ratio: 0.56 (95% CI 0.41–0.77)

Absolute Event Rate: 4.95% vs 13.85%

p-value: p=<0.001

In patients with hypertension, engaging in moderate-to-vigorous physical activity of 7.5 to < 15 MET-h/week is associated with the lowest risks of cardiocerebrovascular and all-cause mortality.

Limitations

Physical activity volume was self-reported via questionnaire, which may be subject to recall bias
Other sources of daily physical activity (e.g., work, household) were not included
Fluctuation of individual physical activity volume during follow-up was not considered
Causes of hypertension were unavailable, meaning secondary hypertension might be included
Observational design cannot establish a causal relationship

Cite This Study

synapsesocial.com/papers/6aa12ba925b16df109667975 https://doi.org/10.3389/fcvm.2022.844680

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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