Key result
SAVR in patients aged ≥80 carries ~190% higher 5-year mortality risk versus those <70.
Why the study?
Does surgical aortic valve replacement result in acceptable morbidity and mortality outcomes in patients aged ≥80 years compared to younger patients?
Cohort (n=351)
Does surgical aortic valve replacement result in acceptable morbidity and mortality outcomes in patients aged ≥80 years compared to younger patients?
Hazard Ratio: 2.9 (95% CI 1.42–5.92)
Absolute Event Rate: 34% vs 10%
p-value: p=0.003
Surgical aortic valve replacement in octogenarians yields satisfactory 5-year survival and significant functional improvements, despite a higher risk of postoperative delirium and infections compared to younger patients.
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Octogenarians face higher post-SAVR mortality; leaves open whether refined selection improves long-term outcomes in this group.
Hussain et al. (2018) conducted a cohort in severe aortic stenosis (n=351). Age ≥80 years vs. Age <70 years was evaluated on 5-year all-cause mortality (HR 2.90, 95% CI 1.42-5.92, p=0.003). Patients aged ≥80 years undergoing surgical aortic valve replacement had a higher 5-year mortality risk compared to those <70 years (34% vs 10%; HR 2.90, 95% CI 1.42-5.92, P=0.003).
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