June 29, 2016Veterinary ResearchOpen Access

The outcome of experimentally induced inclusion body hepatitis (IBH) by fowl aviadenoviruses (FAdVs) is crucially influenced by the genetic background of the host

Q: What are the key findings of this study?

Specific pathogen-free broiler chickens were highly susceptible to experimentally induced inclusion body hepatitis, with mortalities of 96-100% compared to 8-20% in layer chickens.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Inclusion body hepatitis (IBH) (n=141). Intervention: Fowl aviadenovirus (FAdV) oral inoculation vs. SPF layers (genetic background comparison) and uninoculated controls. Primary outcome: Mortality (p=<0.05).

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Key result

Experimental inclusion body hepatitis drives ~100% mortality in broiler chickens versus layer chickens.

P<0.05
n=141

Why the study?

Does genetic background (broiler vs layer) influence susceptibility and mortality in experimentally induced inclusion body hepatitis by fowl aviadenoviruses?

Population

141 day-old specific pathogen-free (SPF) chickens (81 broilers and 60 layers)

Comparison

Oral inoculation with 0.5 mL of fowl… vs Uninoculated control groups of SPF broilers and…

Design

Preclinical

Follow-up

21 days

Authors

MMMiguel MatosUniversity of Veterinary Medicine Vienna BGBeatrice GraflUniversity of Veterinary Medicine Vienna DLDieter LiebhartUniversity of Veterinary Medicine Vienna

Discussion

Member takes

Implication

May indicate greater IBH risk in broilers than layers; leaves open genetic drivers of susceptibility.

Structured PICO

Does genetic background (broiler vs layer) influence susceptibility and mortality in experimentally induced inclusion body hepatitis by fowl aviadenoviruses?

Population

141 day-old specific pathogen-free broiler and layer chickens experimentally infected with fowl aviadenovirus to evaluate genetic susceptibility to inclusion body hepatitis over 21 days.

Intervention

Oral inoculation with 0.5 mL of fowl aviadenovirus (FAdV)-D (strain 08/18 926) or FAdV-E (strain 13/18 153) at day-old

Comparator

Uninoculated control groups of SPF broilers and SPF layers

Outcome

Mortality and clinical signs up to 21 days post-infectionhard clinical

Main Result

Absolute Event Rate: 100% vs 20%

p-value: p=<0.05

SPF broiler chickens are significantly more susceptible to experimentally induced inclusion body hepatitis by FAdVs compared to SPF layers, evolving into a metabolic disorder with severe hypoglycemia.

Limitations

Further studies are needed to better understand the pathogenesis of IBH in broilers and the involvement of the liver and pancreas in metabolic derangements.
Did not assess glomerular size and cellularity in kidneys by histomorphometric studies to test the glomerulonephritis hypothesis.

Cite This Study

Matos et al. (2016) studied Inclusion body hepatitis (IBH) (n=141). Fowl aviadenovirus (FAdV) oral inoculation vs. SPF layers (genetic background comparison) and uninoculated controls was evaluated on Mortality (p=<0.05). Specific pathogen-free broiler chickens were highly susceptible to experimentally induced inclusion body hepatitis, with mortalities of 96-100% compared to 8-20% in layer chickens.

synapsesocial.com/papers/6aa164f07ead44eb96777b3c https://doi.org/10.1186/s13567-016-0350-0

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The outcome of experimentally induced inclusion body hepatitis (IBH) by fowl aviadenoviruses (FAdVs) is crucially influenced by the genetic background of the host

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

The outcome of experimentally induced inclusion body hepatitis (IBH) by fowl aviadenoviruses (FAdVs) is crucially influenced by the genetic background of the host

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider