Key result
Ticlopidine-induced profound neutropenia mimicking sepsis after stenting resolves promptly upon drug discontinuation.
Case Report (n=1)
Ticlopidine can induce profound neutropenia early in therapy that mimics sepsis, which resolves upon discontinuation.
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May warrant vigilance for early neutropenia in ticlopidine-treated stent patients; single case leaves open need for prospective safety data.
We report a case of ticlopidine-induced profound neutropenia early in the course of therapy, which was manifest as a febrile systemic illness mimicking sepsis. This clinical presentation was potentially indicative of a contaminated intracoronary stent. The patient's signs and symptoms of illness promptly resolved with removal of ticlopidine, and no infection was documented. Review of indications for ticlopidine use, potential adverse effects, and monitoring recommendations are discussed.
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Ochoa et al. (1998) conducted a case report in Ticlopidine-induced neutropenia mimicking sepsis (n=1). Ticlopidine was evaluated on Resolution of signs and symptoms of illness. Ticlopidine-induced profound neutropenia mimicking sepsis early after intracoronary stent placement promptly resolved upon discontinuation of the drug.
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