Key result
Marek's disease virus alters immunoglobulins in distinct phases, causing clinical disease only in susceptible birds.
Population
Five-week-old birds of resistant (N) and susceptible (P) genetic lines
Comparison
Inoculation with the JM strain of Marek's… vs Uninfected control birds
Design
Preclinical
Follow-up
63 days after inoculation
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Genetic resistance shapes sustained antibody responses in this avian model; leaves open relevance to human viral cardiomyopathies.
The study characterizes the differential immunoglobulin and antibody responses to Marek's disease virus in genetically resistant versus susceptible birds.
A 1975 study studied Marek's disease. JM strain of Marek's disease (MD) virus vs. Uninfected control birds was evaluated on Antibody and immunoglobulin levels. Inoculation with Marek's disease virus led to distinct phases of immunoglobulin alterations, with clinical disease occurring only in genetically susceptible birds.
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