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April 1, 1973Avian Pathology

Lack of a threshold of genetic resistance to Marek's disease and the incidence of humoral antibody

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Key result

Genetically resistant Line 6 chickens show ~1 million-fold greater clinical Marek's disease resistance versus Line 7.

Population

Genetically susceptible and genetically resistant chickens, including maternal-antibody-positive and…

Comparison

Challenge exposure to graded doses of Marek's… vs Comparison between genetically resistant and…

Design

Preclinical

Authors

JSJ. Μ. SharmaUniversity of Maryland, Baltimore

Discussion

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Overview

Extreme genetic resistance withstands massive viral doses in poultry; leaves open mechanistic translation to other species or herpesvirus models.

Structured PICO

P
Population
Genetically susceptible (Line 7) and genetically resistant (Line 6) chickens challenged with graded doses of Marek's disease virus.
I
Intervention
Challenge exposure to graded doses of Marek's disease virus.
C
Comparator
Comparison between genetically resistant (Line 6) and susceptible (Line 7) chickens, and between maternal-antibody-positive and negative chickens.
O
Outcome
Resistance to clinical Marek's disease and humoral antibody response (precipitating, virus neutralizing, immunofluorescent).surrogate

Genetically resistant chickens show massive resistance to clinical Marek's disease compared to susceptible lines, though both are equally susceptible to infection and antibody production.

Limitations

  • Genetic homogeneity of maternal antibody positive and negative populations of Line 6 chickens was equivocal, so differences could not be attributed to maternal antibody alone.
  • Genetic homogeneity of maternal antibody positive and negative populations of Line 6 chickens was equivocal

Cite This Study

J. Μ. Sharma (1973) studied Marek's disease. Marek's disease virus challenge vs. Genetically susceptible (Line 7) chickens was evaluated on Clinical Marek's disease. Genetically resistant Line 6 chickens were at least 10(6)-fold more resistant to clinical Marek's disease than susceptible Line 7 chickens upon challenge with Marek's disease virus.

synapsesocial.com/papers/6aa2288a9381edd5a407ee74https://doi.org/10.1080/03079457309353786
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Resistance to Marek's Disease. Delineation of the Response of Genetically Resistant Chickens to Marek's Disease Virus Infection1972 · 48 citations
  2. 2Journal of the National Cancer Institute1969 · 838 citations
  3. 3Influence of Maternal Antibody on Infection with Virulent or Attenuated Marek's Disease Herpesvirus1972 · 29 citations