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June 1, 1974Infection and ImmunityOpen Access

Replication of Marek's Disease Virus in Cell Cultures Derived from Genetically Resistant Chickens

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Key result

Marek's disease virus replicates equally in resistant and susceptible cells, indicating no cellular-level genetic resistance.

Population

Cell cultures derived from genetically resistant (line 6) and susceptible (line 7) chickens

Comparison

Infection with three strains of pathogenic… vs Comparison between cells from resistant and…

Design

Preclinical

Follow-up

about 4 weeks

Authors

JSJ. Μ. SharmaHPH. G. Purchase

Discussion

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Overview

Shifts focus from cellular to systemic factors in Marek's disease resistance; leaves open mechanisms for targeted poultry breeding studies.

Structured PICO

P
Population
In vitro study of cells derived from genetically resistant (line 6) and susceptible (line 7) chickens infected with Marek's disease virus.
E
Exposure
Infection with three strains of pathogenic Marek's disease virus (MDV) (JM, GA, and Id-1)
C
Comparator
Comparison between cells from resistant (line 6) and susceptible (line 7) chickens
O
Outcome
Parameters of replication of Marek's disease virus (MDV)

Genetic resistance to Marek's disease is not expressed at the cellular level, contrasting with lymphoid leukosis viruses.

Cite This Study

Sharma et al. (1974) studied Marek's disease virus infection. Marek's disease virus (MDV) strains (JM, GA, and Id-1) vs. Cells from susceptible chickens (line 7) was evaluated on Virus replication parameters, cytopathic effects, and virus-induced antigens. Marek's disease virus replicated equally well in cell cultures derived from genetically resistant and susceptible chickens, indicating a lack of expression of genetic resistance at the cellular level.

synapsesocial.com/papers/6aa2288a9381edd5a407ee72https://doi.org/10.1128/iai.9.6.1092-1097.1974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of a threshold of genetic resistance to Marek's disease and the incidence of humoral antibody1973 · 12 citations
  2. 2Pathogenicity and Antigenicity of Clones from Strains of Marek's Disease Virus and the Herpesvirus of Turkeys1971 · 75 citations
  3. 3Genetic Resistance to Marek's Disease. Delineation of the Response of Genetically Resistant Chickens to Marek's Disease Virus Infection1972 · 49 citations
  4. 4The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell Culture1969 · 251 citations
  5. 5Marek's Disease Herpesvirus: In Vivo and in vitro Infection of Kidney Cells of Different Genetic Strains of Chickens1969 · 28 citations