May 16, 2012Civil War Book ReviewOpen Access

Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis

Q: What are the key findings of this study?

The adrenergic alpha 1 (ADRA1) receptor pathway was significantly associated with hypertension (p<0.0009) and diastolic blood pressure (p<0.0007) in a pathway-focused analysis of Nigerians.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Hypertension (n=1614). Intervention: Adrenergic alpha 1 (ADRA1) pathway genetic variants vs. Unexposed / lower genetic risk score. Primary outcome: Association of the ADRA1 pathway with hypertension (p=<0.0009).

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Key result

ADRA1 pathway linked to hypertension and higher diastolic blood pressure in Nigerians.

P<0.0009
n=1,614

Population

1614 Nigerians with genome-wide data

Design

Cross-sectional

Authors

NRNicholas P. RederSeattle University BTBamidele O. TayoGeneral / Preventive / Lipids BSBabatunde SalakoNigerian Institute of Medical Research

Discussion

Member takes

Implication

Supports ADRA1 pathway involvement in hypertension among Nigerians; hypothesis-generating and requires prospective validation before clinical consideration.

Study Design

Type

Observational (n=1,614)

Structured PICO

Population

1,614 unrelated adult Nigerians with normal or elevated blood pressure, genotyped to assess pathway-focused genetic associations with hypertension.

Outcome

Association with hypertension, systolic blood pressure (SBP), and diastolic blood pressure (DBP)surrogate

Main Result

p-value: p=<0.0009

A pathway-focused genetic analysis identified a significant association between the adrenergic alpha-1 receptor pathway and hypertension in a Nigerian cohort.

Limitations

Increased need for adequate SNP coverage due to testing a limited area of the genome
Subjective nature of pathway selection, including the level of evidence needed, genes included, and length of regulatory regions
Vulnerability to issues of external validity due to the increased importance of common ancestral genetic background in pathway study populations
Significance of individual SNPs should be taken with caution due to multiple testing penalties
Requires further studies in similar and other populations to assess generalizability

Cite This Study

Reder et al. (2012) conducted an observational in Hypertension (n=1,614). Adrenergic alpha 1 (ADRA1) pathway genetic variants vs. Unexposed / lower genetic risk score was evaluated on Association of the ADRA1 pathway with hypertension (p=<0.0009). The adrenergic alpha 1 (ADRA1) receptor pathway was significantly associated with hypertension (p<0.0009) and diastolic blood pressure (p<0.0007) in a pathway-focused analysis of Nigerians.

synapsesocial.com/papers/6aa235750c07007fbcb2b6a7 https://doi.org/10.1371/journal.pone.0037145

Topics

Hypertension management

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Implication

Supports ADRA1 pathway involvement in hypertension among Nigerians; hypothesis-generating and requires prospective validation before clinical consideration.

Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider