Key result
Isolated obesity in children is independently associated with early myocardial deformation changes, most strongly with LV average circumferential strain (β-coefficient 0.74; P=0.003).
Why the study?
Does isolated obesity cause early myocardial deformation changes in children?
Observational (n=72)
Does isolated obesity cause early myocardial deformation changes in children?
Effect estimate: β-coefficient 0.74
p-value: p=0.003
Isolated obesity in childhood is associated with early structural and myocardial deformation changes, most notably in LV circumferential strain, independent of other cardiovascular risk factors.
May support subclinical LV strain monitoring in obese children; leaves open causality and reversibility pending longitudinal data.
Obesity is considered as a strong risk factor for cardiovascular morbidity and mortality. 3D-wall motion tracking echocardiography (3D-WMT) provides information regarding different parameters of left ventricular (LV) myocardial deformation. Our aim was to assess the presence of early myocardial deformation abnormalities in nonselected obese children free from other cardiovascular risk factors. Thirty consecutive nonselected obese children and 42 healthy volunteer children were enrolled. None of them had any cardiovascular risk factor. Every subject underwent a 2D-echo examination and a 3D-WMT study. Mean age was 13.9 ± 2.56 and 13.25 ± 2.68 years in the nonobese and obese groups, respectively (59.7% and 40.3% male). Statistically significant differences were found for: interventricular septum thickness, LV posterior wall thickness, LV end-diastolic volume, LV end-systolic volume, left atrium volume, LV mass, and lateral annulus peak velocity. Regarding the results obtained by 3D-WMT assessment, all the evaluated parameters were statistically significantly different between the two groups. When the influence of obesity on the different echocardiographic variables was evaluated by means of multivariate logistic regression analysis, the strongest relationship with obesity was found for LV average circumferential strain (β-coefficient: 0.74; r(2): 0.55; P: 0.003). Thus, obesity cardiomyopathy is associated not only with structural cardiac changes, but also with myocardial deformation changes. Furthermore, this association occurs as early as in the childhood and it is independent from any other cardiovascular risk factor. The most related parameter to obesity is LV circumferential strain.
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Saltijeral et al. (2011) conducted an observational in Isolated obesity (n=72). Isolated obesity vs. Healthy nonobese children was evaluated on LV average circumferential strain (β-coefficient 0.74, p=0.003). Isolated obesity in children is independently associated with early myocardial deformation changes, most strongly with LV average circumferential strain (β-coefficient 0.74; P=0.003).
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