Key result
Cerebrovascular pulse wave transit time and carotid β-stiffness link to WMLv independent of IHD history.
Why the study?
It was unknown whether vascular stiffness predicts white matter hyperintensity burden in patients with ischemic heart disease and preserved ejection fraction.
Does vascular stiffness predict white matter hyperintensity burden in ischemic heart disease with preserved ejection fraction?
Observational
Does vascular stiffness predict white matter hyperintensity burden in ischemic heart disease with preserved ejection fraction?
Cerebrovascular pulse wave transit time and carotid β-stiffness are associated with structural white matter damage regardless of heart disease history.
Should not yet change practice in preserved-EF IHD; leaves open causal links between stiffness and white matter lesions.
This study found that patients with ischemic heart disease (IHD) with preserved ejection fraction and normal blood pressures exhibit greater carotid β-stiffness, as well as middle cerebral artery pulsatility and resistive indexes, than controls. White matter lesion volume (WMLv) was not different between vascular pathology groups. Cerebrovascular pulse wave transit time (ccPWTT) and carotid β-stiffness independently associate with WMLv in pooled participant data, suggesting that regardless of heart disease history, ccPWTT and β-stiffness are associated with structural white matter damage.
No takes yet. Share an insight, caveat, or question.
Balestrini et al. (2020) conducted an observational in Ischemic heart disease with preserved ejection fraction. Ischemic heart disease vs. Controls was evaluated on White matter lesion volume (WMLv). Cerebrovascular pulse wave transit time and carotid β-stiffness independently associated with white matter lesion volume, regardless of ischemic heart disease history.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: