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September 10, 2026Interdisciplinary CardioVascular and Thoracic SurgeryOpen Access

Impact of treatment-related complications on long-term outcomes in recurrence-free survivors with locally advanced non-small cell lung cancer after Trimodality therapy

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Authors

KOKazuhiro OkadaKSKen SuzawaHAHideki Aoyama

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Overview

Retrospective study demonstrates chronic lung injury impairs long-term survival in recurrence-free lung cancer survivors after trimodality therapy, indicating the need to minimize treatment morbidity.

Key Points

  • To evaluate the prognostic impact of late treatment-related complications on long-term outcomes among recurrence-free survivors with locally advanced non-small cell lung cancer following trimodality therapy.
  • Retrospective analysis of N = 199 patients undergoing trimodality therapy (induction chemoradiotherapy followed by surgery) between January 1999 and December 2021.
  • Evaluated overall survival and late adverse events among N = 112 recurrence-free survivors (median age 62.5 years; stage II: n = 27, stage III: n = 85) across a median follow-up of 11.5 years using multivariable analysis.
  • Overall survival rates among recurrence-free survivors were 90.0% at 3 years, 84.4% at 5 years, and 71.5% at 10 years.
  • Multivariable analysis identified chronic lung injury extending beyond the anatomical segment as an independent prognostic factor associated with worse long-term survival (P = 0.04).

Cite This Study

Okada et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b9a58559d80afc74dfchttps://doi.org/10.1093/icvts/ivag247
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