Why the study?
Does chronic obstructive pulmonary disease impair left ventricular function in response to an increased pressure load?
Population
27 patients undergoing cardiac catheterization, comprising 16 with chronic obstructive pulmonary disease, 6…
Comparison
Intravenous infusion of methoxamine to increase… vs Responses compared between COPD patients, normal…
Design
Cross-sectional
Key result
Methoxamine infusion in patients with chronic obstructive pulmonary disease produced normal increases in stroke work index (from 40 to 63 g-m/m2) and stroke volume index, demonstrating preserved left ventricular function.
Authors
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COPD does not appear to cause chronic impairment of left ventricular function, as the left ventricle responds normally to an increased pressure load in these patients.
Cross-Sectional (n=27)
No
Does chronic obstructive pulmonary disease impair left ventricular function in response to an increased pressure load?
COPD does not appear to cause chronic impairment of left ventricular function, as the left ventricle responds normally to an increased pressure load in these patients.
Williams et al. (1968) conducted a cross-sectional in Chronic obstructive pulmonary disease (n=27). Methoxamine infusion vs. Control patients with normal cardiopulmonary function and patients with primary myocardial disease was evaluated on Change in stroke work index (SWI) and stroke volume index (SVI) in response to increased afterload. Methoxamine infusion in patients with chronic obstructive pulmonary disease produced normal increases in stroke work index (from 40 to 63 g-m/m2) and stroke volume index, demonstrating preserved left ventricular function.