September 10, 2026Nature Reviews Cardiology
Genetic cardiomyopathy-associated myocarditis
Key result
Genetic variation is linked to susceptibility to acute myocarditis.
Design
Editorial
Authors
Discussion
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Key expert perspectives
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“These findings suggest there should be a low threshold for genetic testing in patients who present with myocarditis—particularly when there isn't an obvious reason for it.”
AHAdam HelmsCardiologist, University of Michigan Frankel Cardiovascular Center
“Sometimes cases of myocarditis are treated with immunosuppression. But this is not the best way to treat hereditary cases. There are no studies to suggest those cases would improve.”
SPSanjay PrasadProfessor of cardiomyopathy, Imperial College London
“it's not just random. For a subset of people, there's a gene that predisposes them to this, or makes them susceptible.”
Implication
Discusses seminal evidence linking genetic variation to susceptibility to acute myocarditis.
Key Points
- To review and discuss seminal evidence demonstrating that underlying genetic variations related to cardiomyopathy predispose individuals to acute myocarditis.
- Expert synthesis evaluating clinical and genomic findings from seminal investigations on acute myocarditis susceptibility.
- Review of genetic variation associated with inherited cardiomyopathy phenotypes and its intersection with inflammatory myocardial disease.
- Identifies a direct association between pathogenic cardiomyopathy-related genetic variants and heightened vulnerability to acute myocarditis.
- Demonstrates that genetic background significantly influences inflammatory myocardial responses to environmental triggers.
Cite This Study
Lerchner et al. (2026) studied this question. Genetic variation is linked to susceptibility to acute myocarditis.