May 13, 2011The Open Cardiovascular Medicine JournalOpen Access

Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease

Q: What are the key findings of this study?

Elevated serum levels of MMP-1, MMP-9, and IL-6 were significantly associated with more extensive and severe coronary artery disease, with MMP-1 showing a strong correlation with the Gensini score (r = 0.717).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease (n=134). Intervention: Elevated serum levels of MMP-1, MMP-9, and IL-6 vs. Normal coronary arteries (controls) or lower severity CAD. Primary outcome: Correlation between MMP-1 levels and angiographic Gensini score (r = 0.717, p=<0.001).

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Key result

Elevated MMP-1, MMP-9, and IL-6 are associated with severe CAD, with MMP-1 correlating at ~0.72.

r = 0.717
P<0.001
n=134

Population

134 consecutive patients who underwent coronary angiography, divided into stable angina pectoris, unstable…

Design

Cross-sectional

Authors

ATAslı TanındıUfuk University

Discussion

Member takes

Implication

MMP-1, MMP-9, and IL-6 levels were associated with CAD severity; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=134)

Multicenter

Structured PICO

Population

134 patients undergoing coronary angiography for stable angina pectoris or acute coronary syndromes, along with controls having normal coronary arteries, evaluated for biomarker levels.

Outcome

Relationship between serum concentrations of MMP-1, MMP-9, TIMP-1 and IL-6 and clinical presentation, risk factors, and angiographic severity (Gensini score)surrogate

Main Result

Effect estimate: r = 0.717

p-value: p=<0.001

Serum levels of MMP-1, MMP-9, and IL-6 are elevated in patients with acute coronary syndromes and correlate significantly with the angiographic extent and severity of coronary artery disease.

Limitations

Timing of blood sampling could not be fixed for NSTEMI and USAP patients due to variable times between chest pain onset and hospital admission.

Cite This Study

Aslı Tanındı (2011) conducted an observational in Coronary artery disease (n=134). Elevated serum levels of MMP-1, MMP-9, and IL-6 vs. Normal coronary arteries (controls) or lower severity CAD was evaluated on Correlation between MMP-1 levels and angiographic Gensini score (r = 0.717, p=<0.001). Elevated serum levels of MMP-1, MMP-9, and IL-6 were significantly associated with more extensive and severe coronary artery disease, with MMP-1 showing a strong correlation with the Gensini score (r = 0.717).

synapsesocial.com/papers/6aa2bfb40fc92d3596e56eea https://doi.org/10.2174/1874192401105010110

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Implication

MMP-1, MMP-9, and IL-6 levels were associated with CAD severity; hypothesis-generating and requires prospective validation before clinical use.

Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

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Also Consider