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September 1, 2026Journal of Clinical HypertensionOpen Access

Daytime systolic ARV ≥11.4 mmHg is linked to ~436% higher odds of arterial stiffness.

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Why the study?

This study evaluated the relationship between Average Real Variability and arterial stiffness and sought to identify clinically relevant ARV thresholds associated with increased cfPWV.

Is Average Real Variability (ARV) of blood pressure associated with increased arterial stiffness in adults?

Population

315 adults undergoing 24-h ambulatory blood pressure monitoring and cfPWV assessment

Comparison

ARV indices compared against arterial stiffness (cfPWV ≥10 m/s)

Design

Observational cross-sectional study

Key result

Daytime systolic Average Real Variability ≥11.4 mmHg was independently associated with increased arterial stiffness (OR 5.36; 95% CI 1.70-17.04; p < 0.01).

Authors

SWStanisław WasiliewDLDawid LipskiLCLudwina Chicheł‐Szczepaniak

Discussion

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Overview

Highlights BP variability as stiffness marker in hypertension; hypothesis-generating, should not change practice yet.

Study Design

Type

Observational (n=315)

Structured PICO

Is Average Real Variability (ARV) of blood pressure associated with increased arterial stiffness in adults?

P
Population
315 adults who underwent 24-h ambulatory blood pressure monitoring and carotid-femoral pulse wave velocity assessment.
E
Exposure
Average Real Variability (ARV) of blood pressure (specifically daytime systolic ARV ≥11.4 mmHg)
C
Comparator
Lower ARV values
O
Outcome
Increased arterial stiffness defined as cfPWV ≥10 m/ssurrogate

Main Result

Odds Ratio: 5.36 (95% CI 1.7–17.04)

p-value: p=< 0.01

Daytime systolic blood pressure variability (ARV ≥11.4 mmHg) is a strong independent predictor of increased arterial stiffness, highlighting its potential as a marker for early vascular damage.

Cite This Study

Wasiliew et al. (2026) conducted an observational in Increased arterial stiffness (n=315). Daytime systolic Average Real Variability (ARV) ≥11.4 mmHg was evaluated on Increased arterial stiffness (cfPWV ≥10 m/s) (OR 5.36, 95% CI 1.70-17.04, p=< 0.01). Daytime systolic Average Real Variability ≥11.4 mmHg was independently associated with increased arterial stiffness (OR 5.36; 95% CI 1.70-17.04; p < 0.01).

synapsesocial.com/papers/6aa2d02a92dfe0a384a7366fhttps://doi.org/10.1111/jch.70355
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