Key result
Increasing tissue factor density or exposure area enhances thrombin and fibrin generation ~threefold.
Population
Human whole blood perfused in an eight-channel microfluidic device and a computational model of clot formation
Comparison
Varying tissue factor surface density and… vs Different levels of TF surface density and…
Design
Preclinical
Authors
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Should not alter clinical thrombosis management; leaves open translation of tissue factor density effects to human venous disease.
Tissue factor surface density and exposure area independently enhance clot occlusivity and resistance to blood flow under venous shear, providing insights into thrombus growth dynamics.
Govindarajan et al. (2018) studied Thrombosis. Tissue factor surface density and exposure area vs. Lower tissue factor density and shorter exposure area was evaluated on Clot growth, structure, and mechanical properties. Increasing tissue factor surface density or exposure area enhanced platelet deposition by approximately twofold and thrombin/fibrin generation by greater than threefold.
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