Key result
Gene probe assays detected more poliovirus-positive water samples than cell culture, demonstrating a 100% correlation between digoxigenin and single-stranded [32P]RNA probes.
Population
Concentrated water samples (environmental samples)
Comparison
Five nonradioactive probe assays vs Two isotopic assays and cell culture
Design
Other
Authors
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May improve poliovirus detection sensitivity in water; leaves open standardization versus cell culture for routine surveillance.
Nonradioactive probe assays are more sensitive than cell culture for detecting poliovirus in environmental water samples.
Moore et al. (1993) studied this question. Gene probe assays detected more poliovirus-positive water samples than cell culture, demonstrating a 100% correlation between digoxigenin and single-stranded [32P]RNA probes.
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