Key result
HF and cardiac allograft recipients show higher sTNF receptors and TNF-alpha binding capacity than controls.
Population
11 patients with heart failure and 15 cardiac allograft recipients, plus controls
Design
Cross-sectional
Authors
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Elevated sTNF receptors may buffer TNF-alpha bioavailability in HF and transplant recipients; leaves open any link to immunosuppression pending prospective validation.
Observational (n=26)
p-value: p=<0.001
In heart failure and post-transplant patients, elevated sTNF-receptors decrease TNF-alpha bioavailability, which may contribute to an immunosuppressed state despite no peripheral TNF-alpha activation.
Iza van Riemsdijk-van Overbeeke (1999) conducted an observational in Heart failure and heart transplantation (n=26). Heart failure and heart transplantation vs. Controls was evaluated on sTNF receptors levels (p=<0.001). Patients with heart failure and cardiac allograft recipients had significantly higher sTNF receptor levels (P<0.001) and increased TNF-alpha binding capacity (P<0.05) compared to controls.
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